Studying the effect of morphine on PC12 cells with molecular radar

Molecular Radar (MR) [ 1 ] is a new method to detect biological processes in living cells at the level of molecular, it is also the newest means to get intracellular information. In this paper we study the effect of morphine on PC12 cells by using MR. The results show that the effect of morphine on PC12 cells is time- and concentration-dependent Morphine treating for short time induces the increase and fluctuation of intracellular [Ca 2 + ], while morphine treating for long time induces chromatin condensation, loss of mitochondria membrane potential and apoptosis.