Health-related quality of life after anonymous nondirected living liver donation: A multi-center collaboration.

Literature on living nondirected liver donation is sparse. The purpose of this study was to assess health-related quality of life (HR-QOL) in anonymous nondirected living liver donors (ND-LLDs). ND-LLDs at three centers: University of Alberta (n=12), University of Colorado (n=12), and University of Southern California (n=12) were surveyed. Thirty donors (83%) responded to the Donor Quality of Life (USC DQLS) and Short-Form 36 (SF-36). Most respondents (n=15, 50%) donated their left lateral segment, 27% right lobe, and 23% left lobe. The majority were female (67%) and mean age was 38.9±11.2 years at donation. Median follow-up was 1.1 [IQR 0.4-3.3] years. Approximately 37% had previously donated a kidney. Eleven experienced ≥1 post-operative complication, with only one Clavien-Dindo IIIb. Most reported minimal impact on school or work performance, all felt positive or neutral about their overall health since donation, and none expressed post-donation regrets. No donor reported impacts on health insurability, and three of four respondents attempting to purchase life insurance post-donation were successful. ND-LLD SF-36 outcomes were similar to U.S. population norms. Overall, ND-LLDs demonstrated acceptable HR-QOL after donation and are appropriate candidates for partial liver donation. Based on evaluation of donation impact, consideration should be given to post-donation support strategies.