Advances in the Applications of Single-cell Transcriptome Sequencing in Tumor Research

Single-cell RNA sequencing (scRNA-seq) is a technology for analyzing complex tissue transcription at single cell level to identify differential gene expression due to mutations in unicellular genomes, as well as novel cell-specific markers and cell types. ScRNA-seq plays an important role in all aspects of tumor research. Fourty-nine literatures were used to review focuses on the principles of scRNA-seq, with emphasis on its application in tumor heterogeneity, pathogenesis, and treatment. The scRNA-seq provides new techniqueor tumor research.