High mobility group box 1 and refeeding-resistance in anorexia nervosa

Anorexia nervosa (AN) is a serious disorder affecting adolescents and young adults, and decreases quality of life over long period.1 Successful weight restoration is an important prognostic factor for disease outcome;1 however, the underlying mechanism of refeeding-resistance (RR), a core psychopathology relevant to 'ambivalent' eating behaviors, remains unclear in this disorder.2, 3, 4