Stability indicating method for sodium montelukast in pharmaceutical preparations by micellar electrokinetic capillary chromatography

A simple, reliable micellar electrokinetic chromatography method (MEKC) for the determination of sodium montelukast in coated tablets was developed and validated. Successful results were obtained with 10 mmol L -1 borate buffer and 30 mmol L -1 sodium dodecyl sulfate at pH 9.4, injection time of 5.0 s, an applied voltage of 25 kV and a column temperature of 25 °C. The detector response for sodium montelukast was linear over the concentration range from 20 to 100 μg mL -1 (r = 0.9995). The intra and inter-day precision showed suitable results (RSD < 1.46%). The analytical method accuracy was 99.67% (RSD = 1.11 %). The limits of detection and quantitation were 0.75 and 2.00 μgmL -1 respectively. The method demonstrated robustness and showed to be viable for the sodium montelukast determination in pharmaceutical dosage form.