Microstructural Control of Polymers Achieved Using Controlled Phase Separation During 3D Printing with Oligomer Libraries: Dictating Drug Release for Personalized Subdermal Implants
2020
Controlling the
microstructure of materials by means of phase separation is a versatile tool for
optimizing material properties. In this study, we show that ink jet 3D printing
of polymer blends gives rise to controllable phase separation that can be used to
tailor the release of drugs. We predicted phase separation using high
throughput screening combined with a model based on the Flory-Huggins
interaction parameter, and were able to show that drug release from 3D printed
structures can be predicted from observations based on single drops of mixtures.
This new understanding gives us hierarchical compositional control, from
droplet to device, allowing release to be ‘dialed up’ without any manipulation
of geometry. This is an important advance for implants that need to be
delivered by cannula, where the shape is highly constrained and thus the usual geometrical
freedoms associated with 3D printing cannot be exploited, bringing a hitherto
unseen level of understanding to emergent material properties of 3D printing.
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