Association between HLA rs3129882 polymorphism and Parkinson's disease: a meta-analysis

OBJECTIVE : As one of potential candidate genes for the risk of Parkinson's dis - ease (PD), the HLA-DRA/PARK18 (rs3129882, A > G) gene has been studied extensively. However, direct evidence for the genetic association stud - ies between PD and rs3129882 remains incon - clusive.The aim of our meta-analysis was to de - termine a more reliable association between the rs3129882andPD. MATERIALS AND METHODS: Comprehen - sive search strategy was used for electronic searches through PubMed, Elsevier, Springer Link, CNKI (Chinese National Knowledge Infra - structure) and WanFang (Chinese) databases to evaluate the association between rs3129882 and PD risk. Data were extracted and the odd ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Finally, we performed a meta- analysis of 13 appropriate papers by using a to - talof11951patientsand11902controls. RESULTS: The meta-analysis showed no sig - nificant association between rs3129882 and PD risk in all four models (the allele model, domi - nant model, homozygote model and the reces - sive model). In allele model, the result was OR = 1.043 (95% CI = 0.978, 1.113). Moreover, this as - sociation remained no significant in the sub - groupanalysisstratifiedbyethnicity. CONCLUSIONS: In current meta-analysis, no significant association was found for rs3129882 and PD risk. And more well-designed primary re - searches will be needed to further evaluate the interaction of rs3129882 polymorphism and the susceptibilityofPD .