Electrical stimulation-evoked release of endogenous aspartate from rat medulla oblongata slices : effects of inhibitors of aspartate aminotransferase and GABA transaminase

The effects of aminooxyacetic acid (AOAA), an aspartate aminotransferase (AAT) inhibitor, L-canaline, an ornithine aminotransferase inhibitor, and γ-acetylenic GABA and gabaculine, both γ-aminobutyric acid transaminase (GABA-T) inhibitors, on the release of aspartate from slices of rat medulla oblongata and hippocampus were studied. We determined whether aminooxyacetic acid affected the release of endogenous aspartate in order to investigate the participation of AAT in the synthesis of the transmitter pool of aspartate