The acute dose-dependent effects of ethanol on canine myocardial perfusion

Abstract The acute effects of ethanol (1.0 g/kg and 1.5 g/kg, n = 4 and n = 5, yielding blood concentrations of 1.3 ± 0.2 mg/ml and 2.4 ± 0.3 mg/ml) on myocardial perfusion were studied in anesthetized, thoracotomized, artificially ventilated dogs by using a radioactive microsphere technique. The control group ( n = 5) received saline. The smaller dose of ethanol decreased perfusion in the left ventricular myocardium from 0.737 ± 0.122 to 0.555 ± 0.122 ml/g/min (NS), whereas the greater dose nonsignificantly increased it, from 0.744 ± 0.115 to 0.819 ± 0.119 ml/g/min ( p p p