High prevalence of thyroid disorders in relatives of patients with familial papillary thyroid cancer

In the familial form of papillary thyroid cancer (PTC), two or more members of the same family have to be affected with PTC. Prevalence is around 5% of all PTC. We performed a clinical analysis in 79 relatives of 16 patients of 7 unrelated kindred with the diagnosis of familial papillary thyroid carcinoma (FPTC). The results were compared with a control group. Thyroid palpation and TSH and TPO-Ab assessment was carried out in the relatives without a diagnosed PTC. Additionally, molecular analysis was performed in the sixteen affected patients. Clinical screening of the 79 family members showed the presence of goiter in 22/79 (29 %). This frequency was much higher than that observed in the control group (8.7%), p En la forma familiar del carcinoma papilar de tiroides (CPT), dos o mas miembros de la misma familia deben presentar CPT. Esta entidad ocurre en aproximadamente el 5% de todos los CPT. En este estudio, realizamos una evaluacion de 79 familiares de 16 pacientes con diagnostico de carcinoma papilar familiar (CPF) provenientes de 7 familias diferentes. Los resultados se compararon con los hallados en un grupo control. Se realizo palpacion tiroidea y medicion de TSH y anticuerpos anti-tiroperoxidasa (TPO-Ab) en todos los familiares. Ademas, se llevo a cabo el analisis molecular en los 16 sujetos que presentaban el diagnostico de CPF. La evaluacion de los 79 familiares de estos pacientes demostro la presencia de bocio en 22/79 (29%). Esta frecuencia fue mucho mayor que la observada en el grupo control (8.7%), p