Association of preadmission metformin use and mortality in patients with sepsis and diabetes mellitus: A systematic review and meta-analysis of cohort studies 11 Medical and Health Sciences 1117 Public Health and Health Services

Background Recent studies have reported that preadmission metformin users had lower mortality than non-metformin users in patients with sepsis and diabetes mellitus; however, these results are still controversial. Therefore, we conducted a systematic review and meta-analysis of published observational cohort data to determine the association between preadmission metformin use and mortality in septic adult patients with diabetes mellitus.