Clinical Characteristics and Immunohistochemistry of Gastrointestinal Stromal Tumors

Objective To investigate the clinical characteristic and immunohistochemistry of the gastrointestinal stromal tumors(GISTs).Methods Clinicopathologic features of GISTs were evaluated.Specimens obtained from patients who had undergone surgical resection for suspected GISTs of the gastrointestinal tract were first studied by light microscopy,than expression of CD117,CD34,viementin,desmen etc.were examined with SP method progressively.GISTs were defined as CD117-positive or CD34-positive,desmin-negative tumors.Results Forty two patients with GISTs were identified. The primary tumor locations were the stomach(n=28),small bowel(n=12),rectum、mesentery and omentum(n=1,respectively).The main clinical manifestations included abdominal pain(18 cases),gastrointestinal bleeding(17 cases),abdominal mass(10 cases).A total of 42 patients were 12 benign,10 borderline,and 20 malignant cases.Histology revealed typical GIST features with spindle(60%),epithelioidl(13.3%),or mixed appearance(26.7%).Expression of CD117,CD34,vimentin was 100%,100% and 97.6% while S-100 was 11.9%,smoothmuscle actins 4.8%,but negative for desmin.Conclusion GISTs are located in the stomach and small intestine predominantly.CD117,CD34 can be used to diagnose GISTs as an immunomarker.