Evaluation of the Effectiveness of a Vancomycin Nomogram at Predicting Trough Levels within a Therapeutic Range

Objectives: The aim of this study was to assess the ability of a vancomycin nomogram to effectively predict vancomycin serum trough concentrations within the desired 15-20 mg/L therapeutic range. Methods: A retrospective chart review was performed on a randomized sample of trough concentrations from adult patients at HVMC (Holston Valley Medical Center) receiving intravenous vancomycin dosing regimens determined by the vancomycin nomogram over an eight-month span. Key findings: 102 patients were included in the study. Trough concentrations ranged from 3.5 mg/L to 40.8 mg/L with 36 (35.2%) patients having trough levels within the desired range of 15-20 mg/L. In addition, 75 (73.5%) patients had trough levels within the range of 10-25 mg/L. Conclusion: This study demonstrated that the vancomycin nomogram at HVMC is an effective dosing tool that provides consistency among multiple pharmacists and predictable serum trough concentrations.