Viral control in chronic HIV-1 subtype C infection is associated with enrichment of p24 IgG1 with Fc effector activity

Amy W. Chung,Jenniffer M. Mabuka,Bongiwe Ndlovu,Anna Licht,Hannah Robinson,Yathisha Ramlakhan,Musie Ghebremichael,Tarylee Reddy,Philip J. R. Goulder,Bruce D. Walker,Thumbi Ndung'u,Galit Alter

Viral control in chronic HIV-1 subtype C infection is associated with enrichment of p24 IgG1 with Fc effector activity

2018

Amy W. Chung
Jenniffer M. Mabuka
Bongiwe Ndlovu
Anna Licht
Hannah Robinson
Yathisha Ramlakhan
Musie Ghebremichael
Tarylee Reddy
Philip J. R. Goulder
Bruce D. Walker
Thumbi Ndung'u
Galit Alter

Objective:Postinfection HIV viral control and immune correlates analysis of the RV144 vaccine trial indicate a potentially critical role for Fc receptor-mediated antibody functions. However, the influence of functional antibodies in clade C infection is largely unknown.Design:Plasma samples from 361

Keywords:

Virology
Immunology
Effector
Medicine
Subclass
Immune system
Innate immune system
Natural killer cell degranulation
Antibody-dependent cell-mediated cytotoxicity
Antibody
Human leukocyte antigen
Isotype

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