Highly Enantioselective Synthesis of α-Azido-β-hydroxy Methyl Ketones Catalyzed by a Cooperative Proline—Guanidinium Salt System.

Angel Martinez‐Castaneda,Kinga Kędziora,Iván Lavandera,Humberto Rodriguez‐Solla,Carmen Concellón,Vicente del Amo

Highly Enantioselective Synthesis of α-Azido-β-hydroxy Methyl Ketones Catalyzed by a Cooperative Proline—Guanidinium Salt System.

2014

Angel Martinez‐Castaneda
Kinga Kędziora
Iván Lavandera
Humberto Rodriguez‐Solla
Carmen Concellón
Vicente del Amo

The first enantioselective synthesis of α-azido-β-hydroxy ketones via direct intermolecular aldol reaction of azidoacetone and aromatic aldehydes is described.

Keywords:

Proline
Enantioselective synthesis
Aldol reaction
Organocatalysis
Chemistry
Catalysis
Intermolecular force
Organic chemistry

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