TIMING OF PROPHYLACTIC ANTIBIOTICS IN TRAUMA AND ORTHOPAEDIC PATIENTS

IntroductionPerioperative antibiotic prophylaxis use in modern orthopaedic procedures is well established. Studies have shown significant reduction in risk of post-operative infections. However, as effectiveness of these antibiotics is dependent on achieving high serum and tissue concentrations that exceed the minimum inhibitory concentrations of infective organisms for operation duration, the timing of prophylaxis is crucial. Although, optimal timing for administering prophylaxis varies in the literature, 30 to 60 minutes prior to skin incision or inflation of tourniquet is considered best standards.ObjectivesTo audit our practice of timing of administration of perioperative prophylactic antibiotics in trauma and orthopaedic procedures.MethodsA double-centre prospective analysis was conducted over a period of 2 week (trauma) and 2 months (elective). Centre A involved trauma cases where centre B involved elective Total Knee Arthroplasty cases. Patients were excluded if they were already on regular antibio...