Phase I/II randomized trial of dendritic cell vaccination with or without cyclophosphamide for consolidation therapy of advanced ovarian cancer in first or second remission

Christina S. Chu,Jean D. Boyer,Daniel S. Schullery,Phyllis A. Gimotty,Victoria Gamerman,James Bender,Bruce L. Levine,George Coukos,Stephen C. Rubin,Mark A. Morgan,Robert H. Vonderheide,Carl H. June

Phase I/II randomized trial of dendritic cell vaccination with or without cyclophosphamide for consolidation therapy of advanced ovarian cancer in first or second remission

2012

Christina S. Chu
Jean D. Boyer
Daniel S. Schullery
Phyllis A. Gimotty
Victoria Gamerman
James Bender
Bruce L. Levine
George Coukos
Stephen C. Rubin
Mark A. Morgan
Robert H. Vonderheide
Carl H. June

Purpose In spite of increased rates of complete response to initial chemotherapy, most patients with advanced ovarian cancer relapse and succumb to progressive disease. Immunotherapy may have potential for consolidation therapy.

Keywords:

Ovarian cancer
Randomized controlled trial
Clinical trial
Immunotherapy
Immunology
Oncology
Progressive disease
Cyclophosphamide
Vaccination
Medicine
Internal medicine
Chemotherapy

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