Immunological memory induced byMycobacterium bovis in inbred mice

Immunological memory was reproduced and studied by subcutaneous vaccination of mice with attenuated strain ofMycobacterium bovis. Ionomycin-resistant cells of CBA mice were for the first time isolated from immune cells and studied as memory T-cells. Previously they were described for another experimental model. They are characterized by high expression of CD3, CD4, CD8, CD28, and α/β-T-cell receptor. The capacity of splenocytes and ionomycin-resistant cells to adoptive transfer of antituberculosis resistance to intact recipients is studied.