Luteolin attenuates glycerol-induced acute renal failure through modulation of Kim-1/NF-κB /Nrf2 signaling pathways

Acute renal failure (ARF) has been documented as a life-threating disease with high morbidity and mortality. We investigated the protective effect of Luteolin against ARF. In the study, forty-male Wistar albino rats were randomly divided into four groups (n = 10). Group A received normal saline. Group B received glycerol (10 ml/kg BW, 50% v/v in sterile saline, i.m.). Groups C and D were pre-treated with Luteolin 100 and 200 mg/k for 7 days, and thereafter administered Glycerol (10 ml/kg BW, 50% v/v in sterile saline, i.m.). Administration of glycerol significantly increased blood pressure, renal oxidative stress, serum creatinine and reduced nitric oxide (NO) bioavailability. Glycerol administration enhanced expressions of kidney injury molecule 1 (Kim-1), nuclear factor kappa beta (NF-κB) and nuclear factor-erythroid-2-related factor 2 (Nrf2). Luteolin pre-treatment normalized blood pressure, reduced markers of oxidative stress, renal damage, and improved NO bioavailability. Together, Luteolin attenuate...