Targeted gene disruption to cure HIV
2013
Purpose of review
Recent clinical research suggests that an HIV-infected patient with lymphoma who was transplanted with bone marrow homozygous for a disrupted mutant CCR5 allele has no remaining HIV replication and is effectively cured of HIV. Here we discuss approaches of disrupting host and viral genes involved in HIV replication and pathogenesis with the aim of curing patients with HIV.
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