FIRST-IN-HUMAN SINGLE-ASCENDING-DOSE STUDY OF IW-1973, A NEW SOLUBLE GUANYLATE CYCLASE STIMULATOR

IW-1973 is an orally active soluble guanylate cyclase (sGC) stimulator that reduces blood pressure (BP) and exhibits anti-fibrotic, anti-inflammatory and organ-protective effects in animal models of systemic hypertension, pulmonary hypertension and heart failure. A Phase 1a first-in-human clinical