A Convenient and Efficient Approach for the Synthesis of New 2-N-substituted 2,5-dihydrofuran-3-carboxamides

In order to obtain potent biological active compounds, a convenient and efficient method for the synthesis of compounds comprising 2-imino-2,5-dihydrofuran, aromatic, sulfamoyl, and heterocyclic fragments has been presented. This environmentally friendly method was based on the reaction of 2-imino-2,5-dihydrofuran-3-carboxamides with analgesic and sulfanilamide drugs and 4-aminoantipyrine in glacial acetic acid and afforded high yields of the products.