ANALYTICAL CHEMISTRY | RESEARCH ARTICLE Voltammetric oxidation of carbenicillin and its electro analytical applications at gold electrode

1 * Abstract: The electrochemical oxidation of carbenicillin disodium salt (CDS) at gold electrode has been investigated for the first time using cyclic, linear sweep, and differential pulse voltammetric techniques. The dependence of the current on pH, concentration, and scan rate were investigated to optimize the experimental conditions for the determination of carbenicillin. The anodic peak was characterized and process was adsorption-controlled. The number of electrons transferred in the oxidation was calculated. A differential pulse voltammetry method with good preci- sion and accuracy was developed for the determination of carbenicillin. The anodic peak current varied linearly with carbenicillin concentration in the range 1.0 × 10 −4 M to 5.0 × 10 −6 M with a limit of detection (LOD) of 6.859 × 10 −7 M and limit of quanti- fication (LOQ) of 2.286 × 10 −6 M. This method can be employed in clinical analysis, quality control, and routine determination of drugs in pharmaceutical analysis.