Clinical study of 99Tcm-N-DBODC5 as a novel myocardial perfusion imaging agent for the diagnosis of coronary artery disease
2014
Objective To investigate the clinical value of 99Tcm-(bis(dimethoxypropylphosphinoethyl)-ethoxyethylamine)-(bis(N-ethoxyethyl)-dithiocarbamato nitride (99Tcm-N-DBODC5) for the detection of coronary artery disease (CAD).Methods From October 2010 to October 2012,46 patients with suspected CAD (31 males,15 females; average age:60 years) were recruited.They all underwent stressrest MPI using both 99Tcm-N-DBODC5 and 99Tcm-MIBI within l week.CAG was carried out within 1 month after MPI and chosen as the gold standard.The diagnostic accordance rate between MPI and CAG were analyzed using Kappa test.The diagnostic efficiency of 99Tcm-N-DBODC5 and 99Tcm-MIBI MPI was compared byx2 test.Results Among the 46 patients,29 were positive and 17 were negative for CAD by CAG.The sensitivity and specificity in the detection of CAD were 86% (25/29) and 65% (11/17) for 99Tcm-MIBI MPI,86% (25/29) and 88% (15/17) for 99Tcm-N-DBODC5 MPI (x2=2.62,P>0.05),respectively.Among the 138 vessels,48 were positive and 90 were negative on CAG.The vessel-based sensitivity,specificity and accuracy for the detection of stenosis were not significantly different between 99Tcm-N-DBODC5 and 99Tcm-MIBI (x2=3.79,all P>0.05).The accordance between 99Tcm-N-DBODC5 MPI and angiography was very good (Kappa=0.73) and moderate for 99Tcm-MIBI MPI (Kappa=0.52).Conclusion 99Tcm-N-DBODC5 might have a potential role as a MPI agent for the diagnosis of CAD.
Key words:
Coronary disease ; Tomography, emission-computed, single-photon; DBODC5 ; MIBI
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
0
Citations
NaN
KQI