Mild and Direct Multiple Deuterium-Labeling of Saturated Fatty Acids

We have established a mild and direct platinum on carbon (Pt/C)-catalyzed multi-deuterium labeling of various saturated fatty acids including bioactive compounds with high deuterium efficiencies in a mixed solvent of isopropyl alcohol and deuterium oxide (i-PrOH)/D2O under neutral conditions at 120 °C without the external addition of deuterium or hydrogen gas.