Impact of obesity on postoperative outcome of hepatic resection for colorectal metastases

Background Outcomes in obese patients who underwent liver resection have been analyzed, but series are heterogeneous and data are controversial. The aim of this study was to analyze short-outcome in obese patients undergone hepatectomy for colorectal metastases. Study design A retrospective analysis on 1,021 consecutive hepatectomies between January 2000 and April 2014 for colorectal metastases was carried out. World Health Organization Classification of obesity (body mass index >30 kg/m 2 ) was used to identify 140 obese patients. Outcomes were compared among obese and nonobese patients. Results Obese patients were mainly male (78%) and were associated more frequently with hypertension (51% vs 29%, P P  = .007), and diabetes (23% vs 10%, P P  = .013) and blood loss (300 ± 420 vs 200 ± 282, P  = .001) were greater in obese patients. Postoperative mortality was nil in obese patients and 0.6% in nonobese patients. Overall morbidity was greater in obese patients (41% vs 31%, P  = .012) mainly related to pulmonary complications (16% vs 9%, P  = .012). Reinterventions were more frequent in obese patients (3.6% vs 1.2%, P  = .004). Median hospital stay was comparable. At pathologic examination, hepatic steatosis was greater in obese (69% vs 43%, P 65 years (odds ratio [OR] 1.43, 95% confidence interval [95% CI] 1.09–1.88), obesity (OR 1.64, 95% CI 1.13–2.38), major hepatectomies (OR 1.65, 95% CI 1.31–2.33), and associated resections (OR 1.67, I95% CI 1.27–2.20) were independent predictors of overall morbidity ( P P  = .041). Conclusion Obese patients undergoing hepatectomy for colorectal metastases should be approached with caution because of an increased risk of postoperative morbidity.