Overcoming Myelin-Associated Inhibition of Axonal Regeneration after CNS Injury

After damage to the peripheral nervous system (PNS), a cascade of events unfold that results in the regeneration of some injured axons towards peripheral targets with an accompanying restoration of function [Pollock, 1995; Terenghi, 1995; Brecknall and Fawcett, 1996]. Our understanding of the mechanisms supporting PNS regeneration has been characterized over the past 5 decades, with the specific roles of glial cells (e.g. Schwann cells) [Bunge, 1994], invading macrophages [Perry and Brown, 1992], extracellular matrix [Martini, 1994] and growth factors [Bunge, 1993] being well documented.