The association of 11C-PIB uptake and cerebral glucose metabolism on 18F-FDG PET in Alzheimer's disease

252 Objectives The aim of this study was to evaluate the association between beta-amyloid deposits measured by 11C-PIB PET and cerebral glucose metabolism measured by 18F-FDG PET. Methods 23 patients with Alzheimer’s disease, 20 with mild cognitive impairment and 24 normal elderly underwent 90-min dynamic PIB PET and static FDG PET. First, z transformations of all images were performed with respect to normal average and SD, and the association of the number and mean z-value of abnormal voxels between corresponding images was evaluated. Further, the correlation of regional PIB uptake and glucose metabolism was evaluated in the entire brain. Results The number of abnormal voxels (r=0.71,p Conclusions This data demonstrated that extent and severity of amyloid deposits was correlated with those of metabolic abnormality in the entire brain, and regional patterns of correlation may reflect the distribution of pathologic and metabolic abnormalities in disease progression.