The SYNTAX score predicts contrast induced nephropathy in patients with acute coronary syndrome

Purpose: Contrast-Induced Nephropathy (CIN) impairs clinical outcomes of patients undergoing Percutaneous Coronary Intervention (PCI). Small number of previous studies reported the predictors of CIN after emergency PCI in patients with Acute Coronary Syndrome (ACS). The aim of this study is to evaluate the predictive value of the SYNTAX score for CIN in patients with ACS undergoing emergency PCI. Methods: Subjects were 154 consecutive patients with acute coronary syndrome who underwent emergent PCI from July 2010 to January 2013. Two patients on hemodialysis were excluded and 152 were analyzed. CIN was defined as an increase in serum creatinine concentration ≥ 25% or ≥0.5 mg/dl above the baseline level within 72 hour of the administration of intravenous contrast. Study patients were divided into two groups (CIN-group and non-CIN-group). The SYNTAX score was compared between the two groups. Predictors of CIN were evaluated using logistic regression analysis. Results: CIN occurred in 21 patients (13.8%). Significantly higher SYNTAX score was observed in CIN-group than non-CIN-group (28.2±12.9 vs. 17.8±9.9, p<0.0001). Logistic regression analysis showed the SYNTAX score was an independent predictor of CIN (each 1 SYNTAX score Odds ratio 1.07, 95% CI: 1.01-1.12, p=0.019) (adjusted by age, sex, hypertension, dyslipidemia, diabetes mellitus, creatinine and contrast media volume). ![Figure][1] SYNTAX score and CIN Conclusion: The SYNTAX score is a useful tool to predict CIN in patients with acute coronary syndrome. [1]: pending:yes