PHYSIOLOGICAL SOCIETY SYMPOSIUM: THE PHYSIOLOGY AND PATHOPHYSIOLOGY OF THE LOWER URINARY TRACT BLADDER INSTABILITY AND DETRUSOR SMOOTH MUSCLE FUNCTION

broughtabout by contraction ofthe detrusor smoothmuscle whichforms the majortissue componentofthe urinary bladder wall. This abnormality can be associated with a number of clinicalconditions andwhenthere is evidence ofassociated neurological deficits it is termeddetrusorhyper-reflexia. An increase in bladder outflow resistance is also associated with detrusorinstability and this is especially prevalent in mendue to the