Maternal T cell responses in pregnancy

mucosa undergoes hundreds of remodelling cycles frommenarche to menopause and uNK and other uterine ILCs (uILC) may regulate tissue homeostasis. During gestation, uNK cells control trophoblast invasion, remodel uterine arteries and regulate fetal growth, thus contributing to laying the foundation in utero for a healthy adult life. uNK cells are indeed at the boundary between two genetically different individuals and combinations of maternal variable NK receptors (KIR) and trophoblast HLA-C are linked to both fetal growth and pregnancy complications underpinned by poor placentation. We will discuss our recent data on human and mouse uILCs.