CDCA2 promotes the proliferation of colorectal cancer cells by activating the AKT/CCND1 pathway in vitro and in vivo

Yifei Feng,Wenwei Qian,Yue Zhang,Wen Peng,Jie Li,Qiou Gu,Dongjian Ji,Zhiyuan Zhang,Qingyuan Wang,Dongsheng Zhang,Yueming Sun

CDCA2 promotes the proliferation of colorectal cancer cells by activating the AKT/CCND1 pathway in vitro and in vivo

2019

Yifei Feng
Wenwei Qian
Yue Zhang
Wen Peng
Jie Li
Qiou Gu
Dongjian Ji
Zhiyuan Zhang
Qingyuan Wang
Dongsheng Zhang
Yueming Sun

Background Cell division cycle associated 2 (CDCA2), upregulated in lung adenocarcinoma and oral squamous cell carcinoma, may be related to some malignant diseases. Nevertheless, its role in colorectal cancer (CRC) remains unknown.

Keywords:

PI3K/AKT/mTOR pathway
Cyclin D1
Cancer research
Carcinoma
Protein kinase B
Medicine
Cell
Colorectal cancer
Adenocarcinoma
In vivo
Carcinogenesis
Downregulation and upregulation
Cell growth
Tumor progression

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