Expression of Survivin in colorectal cancer tissue and its relationship with clinicopathological features

Objective To explore the expression of Survivin in colorectal cancer tissue and its relationship with clinicopathological features. Methods In situ hybridization was used to examine the expression of Survivin mRNA, and immunohistochemical method was used to detect the expression of Survivin protein in 60 cases of colorectal cancer and 30 cases of colorectal normal mucos tissue. The relationship of the expression of Survivin protein with clinicopathological features of colorectal cancer was analyzed. Results The positive expression rate of Survivin protein in colorectal normal mucos tissue (10.00%, 3/30) was lower than that in colorectal cancer tissue (73.33%,44/60), and there was significant difference (P 0.05). Conclusions The specific high expression of Survivin protein has a high correlation with the occurrence, development, infiltration of colorectal cancer. Survivin may be used as a marker for prognosis of patients with colorectal cancer. Key words: Colorectal neoplasms; Immunohistochemistry; In situ hybridization; Survivin