Smith-Lemli-Opitz syndrome associated with Hirschsprung disease, 46,XY female karyotype, and total anomalous pulmonary venous drainage

At this time there is no evidence that oxymetazoline per se causes malformations in animals or humans. We were nevertheless struck by this child's unusual cluster of malformations and the daily use of oxymetazoline during pregnancy. We would welcome other reports of associations between maternal gestational use of oxymetazoline or other sympathomimetic decongestants, and similar malformation clusters. Ingrid A. Holm, Sc.B. Sterling K. Clarren, M.D. Department of Pediatrics University of Washington Children's Orthopedic Hospital and Medical Center Seattle, WA 98105