Chromatin remodeling by the NuRD complex regulates development of follicular helper and regulatory T cells
2018
Lineage commitment and differentiation into CD4 + T cell subsets reflect an interplay between chromatin regulators and transcription factors (TF). Follicular T cell development is regulated by the Bcl6 TF, which helps determine the phenotype and follicular localization of both CD4 + follicular helper T cells (T FH ) and follicular regulatory T cells (T FR ). Here we show that Bcl6-dependent control of follicular T cells is mediated by a complex formed between Bcl6 and the Mi-2β-nucleosome-remodeling deacetylase complex (Mi-2β-NuRD). Formation of this complex reflects the contribution of the intracellular isoform of osteopontin (OPN-i), which acts as a scaffold to stabilize binding between Bcl6 and the NuRD complex that together regulate the genetic program of both T FH and T FR cells. Defective assembly of the Bcl6–NuRD complex distorts follicular T cell differentiation, resulting in impaired T FR development and skewing of the T FH lineage toward a T H 1-like program that includes expression of Blimp1, Tbet, granzyme B, and IFNγ. These findings define a core Bcl6-directed transcriptional complex that enables CD4 + follicular T cells to regulate the germinal center response.
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