Copper(I)-Mediated Synthesis of Trisubstituted 1,2,3-Triazoles

Brian H. M. Kuijpers,Guido C. T. Dijkmans,Stan Groothuys,Peter Jan Leonard Mario Quaedflieg,R. H. Blaauw,Floris L. van Delft,Floris P. J. T. Rutjes

Copper(I)-Mediated Synthesis of Trisubstituted 1,2,3-Triazoles

2005

Brian H. M. Kuijpers
Guido C. T. Dijkmans
Stan Groothuys
Peter Jan Leonard Mario Quaedflieg
R. H. Blaauw
Floris L. van Delft
Floris P. J. T. Rutjes

A copper-catalysed coupling of bromo-alkynes and organic azides is described. This coupling results in the formation of bromo-comaining trisubstituted 1,2,3-triazole derivatives in high yield and a regioselective manner.

Keywords:

Photochemistry
Click chemistry
Copper
Glycopeptide
Organic chemistry
Regioselectivity
Chemistry
triazole derivatives

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