ORIGINAL ARTICLES CARDIOVASCULAR RESPONSE DURING INDUCTION OF ANESTHE- SIA AND TRACHEAL INTUBATION WITH THIOPENTAL ADDED TO FENTANYL, KETAMINE, AND FENTANYL-KETAMINE

SUMMARY This investigation was performed to examine hemodynamic stability for the period of anesthesia induction and intubation, employing thiopental added to fentanyl, thiopental added to ketamine, and thiopental added to fentanyl and ketamine. Methods: Sixty adult patients were randomly assigned to one of three groups corresponding to the agents applied for induction: (a) thiopental (4 mg/kg) added to fentanyl (3µg/kg) (TF, n = 20), (b) thiopental (4 mg/kg) added to ketamine (0.1mg/kg) (TK, n = 20), and (c) thiopental (4 mg/kg) added to fentanyl (3µg/kg) and ketamine (0.1mg/kg) (TFK, n = 20). Hemodynamic responses were evaluated by determining changes in blood pressure (BP) and heart rate (HR) immediately before laryngoscopy and at 1, 3, 5, and 10 min after the beginning of laryngoscopy. Results: BP and HR changes throughout the induction of anesthesia tended to be larger in the TK group than in the TF and TFK groups (P TF > TFK. Heart rate was significantly elevated in TK group compared with TF and TFK groups following laryngoscopy (P TF > TFK. After intubation, BP and HR kept on unchanged matched up to with their pre-intubation levels in the TFK group. Conclusion: A mixture of thiopental added to fentanyl added to ketamine would offer greater reduction of instabilities in hemodynamic variables related with induction of anesthesia and tracheal intubation than mixtures of thiopental added to fentanyl or thiopental added to ketamine.