A New Synthesis of 3,5-Dihydroxy-7-(1-pyrrolyl)-6-heptenoic Acids, a Family of HMGCoA Reductase Inhibitors with Antifungal Activity.

Abstract Starting from a 3,5-dihydroxyheptanoic acid derivative, a new synthesis of pyrrole statins that contain a double bond on the dihydroxyacid chain has been developed. Key steps are N-acylamino acid enamide formation through enamine trapping with aromatic acyl chlorides and subsequent munchnone cycloaddition with activated acetylenes.