Development of benzoyl peroxide loaded nanosponges gel

Objective: Benzoyl peroxide (BPO) is a prominent ingredient in topical acne treatments. The goal of this study was to synthesize Benzoyl peroxide (BPO) nanosponges using various polymers and were designed to deliver a pharmaceutically active ingredient efficiently at minimum dose and also to enhance stability, reduce side effects, and modify drug release profiles. This system can work efficiently for systemic as well as local effect.Methods: Nanosponges were prepared by quasi emulsion solvent diffusion method using different polymers. The best performing nanosponges were integrated into the gel formulation. Prepared gel formulations were evaluated for physical parameters like viscosity, pH, and clarity and in-vitro drug permeation study.Result: The drug release data of selected batch were fitted into different kinetic models which show that the drug release from gel formulations follows zero order release. Selected gel formulation batch was compared with the marketed formulation. Conclusions: Thus it can be concluded that nanosponge delivery system work efficiently for topical delivery of Benzoyl Peroxide.