S. ferritin, il-6 and d-dimer in assessment and prediction of severity in covid-19 patients

Aims & Objectives: Since December 2019, an outbreak caused by Severe Acute Respiratory Syndrome-Corona virus 2 (SARS-CO V -2) emerged in China and quickly turned into pandemic India had 7 42 million and Madhya Pradesh had 157 thousand confirmed cases by 16 October 2020 This outbreak of novel corona virus has put health systems on high alert in India and across the world Our study aimed to assess inflammatory markers (S Ferritin and IL-6) and fibrin degradation product (D-Dimer) in the assessment of disease severity in COVID-19 patients and use of these investigations as prognostic markers Patients/Materials & Methods: It is a retrospective single center study carried out at our institute Data of 150 patients who were confirmed cases of COVID-19 were collected and analyzed Cases were divided into mild, moderate & severe groups by using guidelines provided by MOHFW Laboratory tests included are complete blood count, D-Dimer, S Ferritin and IL-6 Results: 150 patient with laboratory RT-PCR confirmed COVID-19 infection of varying severity were assessed early after their admission The average age of the patients was 50 02 ± 16 1 years There were 76 7% aged 60 years or less and 23 3% aged above 60 years Males were 105(70%) and females were 45(30%) 150 subjects were classified as mild [46(30 7%)], moderate [31(20 7%)] and severe [73(48 7%)] Comparison across three groups mild, moderate and severe showed significant difference in D-Dimer Inflammatory markers S Ferritin and IL-6 were also found to be significantly raised across the severity spectrum as well Discussion & Conclusion: We found that inflammatory markers and fibrin degradation product could assess the severity of patients with COVID-19 and further studies with robust methodologies must be performed to establish them as potential biomarkers in this illness