TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8+ T cells
2015
In the thymus, low-affinity T cell antigen receptor (TCR) engagement facilitates positive selection of the T cell repertoire. Takahama and colleagues now show TCR responsiveness of mature CD8+ T cells is fine-tuned by their affinity for positively selecting peptides in the thymus.
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