Synthesis and antifungal activity of 6,7-bis(arylthio)-quinazoline-5,8-diones and furo[2,3-f]quinazolin-5-ols

Abstract 6,7-Bis(arylthio)-quinazoline-5,8-dione and furo[2,3- f ]quinazolin-5-ol derivatives were synthesized and tested for in vitro antifungal activity against Candida , Aspergillus species, and Cryptococcus neoformans . Among them tested, many of furo[2,3- f ]quinazolin-5-ols and 6,7-bis(arylthio)-quinazoline-5,8-diones showed good antifungal activity. The compounds 4a and 4e completely inhibited the growth of all against Candida and Aspergillus species tested at the MIC level of 12.5 μg/mL. The results suggest that furo[2,3- f ]quinazolin-5-ols and 6,7-bis(arylthio)-quinazoline-5,8-diones would be promising antifungal agents.