AN EFFICIENT SYNTHESIS OF A CHIRAL CARBOCYCLIC 2'-DEOXYRIBONUCLEOSIDE SYNTHON BY DIRECTED REDUCTION

Abstract Directed reduction of the 1,4 hydroxy-ketone 9 and the 1,4 aldehydo-ketone 12 with NaBH(OAc) 3 gave stereoselectively in high yield the 1,4 diol 10 , a key intermediate required in our synthesis of chiral carbocyclic 2′-deoxyribonucleosides.