EFFECT OF ETHIONINE-INDUCED PANCREATIC DAMAGE ON INTESTINAL ENZYME ACTIVITY OF THE RAT.

SummaryRats fed d1-ethionine for 25 days showed a significant decrease in small intestinal trypsin, chymotrypsin and lipase activity when compared to controls. The results suggest that levels of intestinal enzyme activity may be used as a quantitative indicator of pancreatic exocrine damage.We wish to express our gratitude to Dr. David C. H. Sun for helpful criticism of the data and manuscript and to Miss Jeanne Chen for technical advice.