Enantioselective Copper-Catalyzed Conjugate Addition of Trimethylaluminum to β,γ-Unsaturated α-Ketoamides: Efficient Access to γ-Methyl-Substituted Carbonyl Compounds.

Sylvie Goncalves-Contal,Ludovic Gremaud,Alexandre Alexakis

Enantioselective Copper-Catalyzed Conjugate Addition of Trimethylaluminum to β,γ-Unsaturated α-Ketoamides: Efficient Access to γ-Methyl-Substituted Carbonyl Compounds.

2014

Sylvie Goncalves-Contal
Ludovic Gremaud
Alexandre Alexakis

The asymmetric addition of AlMe3 to β,γ-unsaturated α-ketoamides affords 1,4-adducts with perfect 1,4-regioselectivity and good to excellent yields and enantioselectivity.

Keywords:

Addition reaction
Conjugate
Catalysis
Enantioselective synthesis
Copper
Organic chemistry
Chemistry
copper catalyzed

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