CYP2D6 polymorphisms influence the efficacy of adjuvant tamoxifen in Thai breast cancer patients.

Ekaphop Sirachainan,Sureerat Jaruhathai,N. Trachu,Ravat Panvichian,T. Sirisinha,T. Ativitavas,Vorachai Ratanatharathorn,Montri Chamnanphon,Chonlaphat Sukasem

CYP2D6 polymorphisms influence the efficacy of adjuvant tamoxifen in Thai breast cancer patients.

2012

Ekaphop Sirachainan
Sureerat Jaruhathai
N. Trachu
Ravat Panvichian
T. Sirisinha
T. Ativitavas
Vorachai Ratanatharathorn
Montri Chamnanphon
Chonlaphat Sukasem

Aim: We evaluated single nucleotide polymorphisms (SNPs) of CYP2D6 to identify those that influence the efficiency of tamoxifen in adjuvant treatment of breast cancer through a matched case–control study.

Keywords:

Breast cancer
Cancer research
Adjuvant
Tamoxifen
Pharmacology
Single-nucleotide polymorphism
CYP2D6
Medicine
Genotype
Oncology
Pharmacogenetics
Allele frequency
Internal medicine

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