Relationship between zincemia, superoxide dismutase activity and marker of oxidative stress in women with breast cancer
2015
Introduction: studies show changes in zinc metabolism
in women with breast cancer. This mineral has antioxidant
action, and disorders in its biochemical parameters
are related to poor prognosis of the disease and increase
in the carcinogenic process.
Objective: this study evaluated the activity of enzyme
superoxide dismutase and biochemical parameters related
to zinc, and investigated the existence of correlation
between these variables and the marker of oxidative
stress in these patients.
Methods: this was a case-control study with 66 women
aged between 20 and 50 years old, distributed into: case
group (women with breast cancer, n = 34) and control
group (healthy women, n = 32). Zinc intake was analyzed
by three-day food diary, using Nutwin software, version
1.5. Plasma and erythrocyte zinc concentrations
were determined by flame atomic absorption spectrophotometry
method (λ = 213.9). Superoxide dismutase
activity was assessed by Griess colorimetric method, and
plasma thiobarbituric acid reactive substances (TBARS)
were analyzed.
Results and discussion: mean levels of zinc intake, superoxide
dismutase and TBARS were higher than recommended
for the study participants with statistical difference
for enzyme superoxide dismutase (p 0.05).
Conclusions: therefore, it can be assumed that zinc intake
in women with breast cancer does not impact plasma
and erythrocyte concentrations of this mineral. High
superoxide dismutase activity in women with breast cancer may be due to a compensatory mechanism of regulation
via oxidative stress found in this disease.
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