The Impact of Hard Drug Abuse as Risk Factor Prognosis in the Clinical Evolution of Patients with Multiple Sclerosis (P1.409)

Objective: To assess the clinical characteristics of a patient population with MS/IDA upon diagnosis, and to evaluate the impact of IDA on the evolution of MS. Background: There have been publications on the interaction of environmental, metabolic, infectious and other factors as risks for Multiple Sclerosis (MS), as well as on their impact on patient’s quality of life. However, little is known on the role of illegal drug abuse (IDA) on MS. In our therapeutic approach, we must recognize IDA as a risk factor with consequences on the natural history of MS, and consider it upon reaching a therapeutic decision. Design/Methods: Retrospective observational study conducted since 1999 to 2017. Diagnosis of MS was based on Mc Donald’s criteria (2010. Gender, age, clinical characteristics of MS (changes in EDSS, time to disability, cognitive disorders, changes in MRI lesions), associated comorbidities, and onset of IDA were recorded. For evaluation the course of disease in these groups a comparison was performed with control group with same baseline characteristics. Results: Among 1250 referred to the MS clinic, (n) 21 were detected with CDMS and IDA at baseline. Age: 16–48 y.o. Clinical form: n(%): RRMS 17(80,9); SPMS 4(19,04); M/F: n(%) 14 (66,7)/7(33,3). Addictions: Marijuana: 10; marijuana + psychotropic agents + cocaine and/or amphetamines: 11; 14 started IDA Lesion load MRI: n(15); cognitive disorders: n(15); psychiatric disorders: n(12). Changes in EDSS:n(%): 6(28,5) progressed; n(%) 3(14,3)died. Conclusions: Our results show that IDA may coexist with MS and their presence may modify the course of the disease. At time of taking medical decisions with MS patients we must include the screening for IDA with adequate information on the impact of addictions on disability progression and on QoL. Disclosure: Dr. Curbelo has nothing to disclose. Dr. Steinberg has nothing to disclose. Dr. Vazquez has nothing to disclose. Dr. Thomson has nothing to disclose. Dr. Carra has nothing to disclose.