PROPHYLATIC ANTIBIOTIC USE IN TRANSURETHRAL PROSTATIC RESECTION: A META-ANALYSIS

Purpose: We reviewed the efficacy of antibiotic prophylaxis in men undergoing transurethral prostatic resection, a clean contaminated procedure.Materials and Methods: We systematically reviewed randomized controlled trials of antibiotic prophylaxis for transurethral prostatic resection with a meta-analysis of the results. We identified 32 randomized controlled trials with 4,260 participants examining the postoperative bacteriuria incidence. An 8-trial subset with 1,979 participants examined postoperative septicemia occurrence.Results: Prophylactic antibiotic use in patients at low risk undergoing transurethral prostatic resection significantly decreased bacteriuria and clinical septicemia incidence. The bacteriuria incidence decreased from 26% to 9.1% (relative risk reduction 65%, 95% confidence interval −56 to −73). The clinical septicemia incidence decreased from 4.4% to 0.7% (relative risk reduction 77%, 95% confidence interval −55 to −88). Effective antibiotic classes included quinolones, cephalospori...