A Practical Approach for Preparation of 2‐[(Dialkylamino)‐methyl]‐4‐aryl‐2H‐phthalazin‐1‐ones via Mannich Reaction of 4‐Aryl‐2H‐phthalazin‐1‐ones

Abstract Synthesis of 4‐aryl‐2H‐phthalazin‐1‐ones 5 and their successive conversion, via the Mannich reaction into 2‐[(dialkylamino)‐methyl]‐4‐aryl‐2H‐phthalazin‐1‐ones 6, 7, 8, 9 as a way of regiospecific transformation of the 4‐methoxybenzanilide 1, is described. In addition, the compounds 5b and 7 appeared to be effective complexing ligands for such metal as Cu(II), Ni(II), Fe(II), and Fe(III).